Anti-inflammatory effects have been demonstrated in rats. Two studies (n=40 and 168) investigating the efficacy of elk velvet antler supplementation on rheumatoid arthritis found no effect, while a study conducted in people with osteoarthritis (n=53) reported symptomatic relief among participants, modiwake. The small sample sizes may result in the trials being underpowered to detect effects. In vitro laboratory studies have examined mechanisms by which antlers seasonally regenerate both bone and nerve tissues. Limited studies on the growth promoting effects of deer velvet have been conducted in tadpoles and chicks with equivocal findings.
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